•Subfamily Alphaherpesvirinae
Herpes
simplex virus 1 (HSV-1)
Herpes
simplex virus 2 (HSV-2)
Varicella-zoster
virus (VZV=HHV-3)
•Subfamily Betaherpesvirinae
Cytomegalovirus
(CMV=HHV-5)
Human
herpes viruses 6,
7 (HHV-6, HHV-7)
•Subfamily Gammaherpesvirinae
Epstein-Barr
virus (EBV=HHV-4)
Human
herpes virus 8 (HHV-8).
Gamma herpesviruses:
•Infection
specific to T or B lymphocytes;
•Latent
in lymphoid tissue, lymphocytes, salivary glands, epithelial cells of mouth and
pharynx.
•Proliferation
of B-lymphocytes.
EBV
HHV 8
•Transmission:
- Contact of infected lesions;
- HSV 1 = oral-oral; oral-genital;
- HSV 2 = primarily genital-genital.
•Local
multiplication:
- Mucous membranes;
- No systemic illness.
•Virus
spread along neurons.
•Latent
infection – sensory cranio-spinal ganglia
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